Regeneron Pharmaceuticals, Inc. REGN under CEO Leonard S. Schleifer
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THE HEXAGRAM
HEXAGRAM 60 – Chieh – Limitation
Above K’AN THE ABYSMAL, WATER
Below TUI THE JOYOUS, LAKE
A lake occupies a limited space. When more water comes into it, it overflows. Therefore limits must be set for the water. The image shows water below and water above, with the firmament between them as a limit.
The Chinese word for limitation really denotes the joints that divide a bamboo stalk. In relation to ordinary life it means the thrift that sets fixed limits upon expenditures. In relation to the moral sphere it means the fixed limits that the superior man sets upon his actions – the limits of loyalty and disinterestedness.
THE JUDGMENT
LIMITATION.
Success.
Galling limitation must not be persevered in.
Limitations are troublesome, but they are effective. If we live economically in normal times, we are prepared for times of want. To be sparing saves us from humiliation. Limitations are also indispensable in the regulation of world conditions. In nature there are fixed limits for summer and winter, day and night, and these limits give the year its meaning. In the same way, economy, by setting fixed limits upon expenditures, acts to preserve property and prevent injury to the people.
But in limitation we must observe due measure. If a man should seek to impose galling limitations upon his own nature, it would be injurious. And if he should go too far in imposing limitations on others, they would rebel. Therefore it is necessary to set limits even upon limitations
THE IMAGE
Water over lake: the image of LIMITATION.
Thus the superior man
Creates number and measure,
And examines the nature of virtue and correct conduct.
A lake is something limited. Water is inexhaustible. A lake can contain only a definite amount of the infinite quantity of water; this is its peculiarity. In human life too the individual achieves significance through discrimination and the setting of limits. Therefore what concerns us here is the problem of clearly defining these discriminations, which are, so to speak, the backbone of morality. Unlimited possibilities are not suited to man; if they existed, his life would only dissolve in the boundless. To become strong, a man’s life needs the limitations ordained by duty and voluntarily accepted. The individual attains significance as a free spirit only by surrounding himself with these limitations and by determining for himself what his duty is.
THE LINES
Nine in the second place means:
Not going out of the gate and the courtyard
Brings misfortune.
When the time for action has come, the moment must be quickly seized. Just as water first collects in a lake without flowing out, yet is certain to find an outlet when the lake is full, so it is in the life of man. It is a good thing to hesitate so long as the time for action has not come, but no longer. Once the obstacles to action have been removed, anxious hesitation is a mistake that is bound to bring disaster, because one misses one’s opportunity.
THE MOVING HEXAGRAM
HEXAGRAM 03 – Chun – Difficulty at the Beginning
Above K’AN THE ABYSMAL, WATER
Below CHEN THE AROUSING, THUNDER
The name of the hexagram, Chun, really connotes a blade of grass pushing against an obstacle as it sprouts out of the earth hence the meaning, "difficulty at the beginning." The hexagram indicates the way in which heaven and earth bring forth individual beings. It is their first meeting, which is beset with difficulties. The lower trigram Chen is the Arousing; its motion is upward and its image is thunder.
The upper trigram K’an stands for the Abysmal, the dangerous. Its motion is downward and its image is rain. The situation points to teeming, chaotic profusion; thunder and rain fill the air. But the chaos clears up. While the Abysmal sinks, the upward movement eventually passes beyond the danger. A thunderstorm brings release from tension, and all things breathe freely again.
THE JUDGMENT
DIFFICULTY AT THE BEGINNING works supreme success,
Furthering through perseverance.
Nothing should be undertaken.
It furthers one to appoint helpers.
Times of growth are beset with difficulties. They resemble a first birth. But these difficulties arise from the very profusion of all that is struggling to attain form. Everything is in motion: therefore if one perseveres there is a prospect of great success, in spite of the existing danger. When it is a man’s fate to undertake such new beginnings, everything is still unformed, dark.
Hence he must hold back, because any premature move might bring disaster. Likewise, it is very important not to remain alone; in order to overcome the chaos he needs helpers. This is not to say, however, that he himself should look on passively at what is happening. He must lend his hand and participate with inspiration and guidance.
THE IMAGE
Clouds and thunder: The image Of DIFFICULTY AT THE BEGINNING.
Thus the superior man
Brings order out of confusion.
Clouds and thunder are represented by definite decorative lines; this means that in the chaos of difficulty at the beginning, order is already implicit. So too the superior man has to arrange and organize the inchoate profusion of such times of beginning, just as one sorts out silk threads from a knotted tangle and binds them into skeins. In order to find one’s place in the infinity of being, one must be able both to separate and to unite.
1. A different translation is possible here, which would result in a different interpretation:
Difficulties pile up.
Horse and wagon turn about.
If the robber were not there,
The wooer would come.
The maiden is faithful, she does riot pledge herself.
Ten years-then she pledges herself.
Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Tarrytown, NY 10591
United States – Map
Phone: 914-347-7000
Fax: 914-347-2847
Website: http://www.regeneron.com
Details
Index Membership: S&P 600 SmallCap
S&P 1500 Super Comp
Sector: Healthcare
Industry: Biotechnology
Full Time Employees: 1,206
Dr. Leonard S. Schleifer M.D., Ph.D., 58 Co-Founder, Chief Exec. Officer, Pres, Exec. Director and Ex Officio Member of Technology Committee
Business Summary
Regeneron Pharmaceuticals, Inc., a biopharmaceutical company, discovers, develops, and commercializes pharmaceutical products for the treatment of serious medical conditions in the United States. The companys commercial product includes ARCALYST (rilonacept) injection for subcutaneous use for the treatment of cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome and muckle-wells syndrome in adults and children. Its products under Phase III clinical trials include Rilonacept for the prevention and treatment of gout-related flares; VEGF Trap-Eye for eye diseases using intraocular delivery; and Aflibercept for the treatment of oncology. The companys earlier stage clinical programs REGN475, an antibody to nerve growth factor, which is being developed for the treatment of pain; REGN88, an antibody to the interleukin-6 receptor, which is developed in rheumatoid arthritis; REGN421, an antibody to delta-like ligand-4, for the treatment of oncology; REGN727, an antibody to proprotein convertase substilisin/kexin type 9, which is developed for low density lipoprotein cholesterol reduction; and REGN668, an antibody to the interleukin-4 receptor for certain allergic and immune conditions. Regeneron Pharmaceuticals also conducts other preclinical research programs in the areas of oncology and angiogenesis, ophthalmology, metabolic and related diseases, muscle diseases and disorders, inflammation and immune diseases, bone and cartilage, pain, cardiovascular diseases, and infectious diseases. The company has strategic collaboration with sanofi-aventis Group to discover, develop, and commercialize fully human monoclonal antibodies; and Bayer HealthCare LLC for the development of the VEGF-Trap-Eye. Regeneron Pharmaceuticals was founded in 1988 and is based in Tarrytown, New York.
